A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. H...

詳細記述

保存先:
書誌詳細
出版年:Int J Hepatol
主要な著者: Bruckbauer, Antje, Banerjee, Jheelam, Fu, Lizhi, Li, Fenfen, Cao, Qiang, Cui, Xin, Wu, Rui, Shi, Hang, Xue, Bingzhong, Zemel, Michael B.
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Publishing Corporation 2016
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155097/
https://ncbi.nlm.nih.gov/pubmed/28042486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9185987
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