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Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
Bicyclo[1.1.1]pentanes (BCPs) are important bioisosteres of 1,4-disubstituted arenes, tert-butyl and acetylenic groups that can impart physicochemical benefits on drug candidates. Here we describe the synthesis of BCPs bearing carbon and halogen substituents under exceptionally mild reaction conditi...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6001403/ https://ncbi.nlm.nih.gov/pubmed/29997886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01355a |
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