Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection

Chaperones play a pivotal role in protein homeostasis, but with age their ability to clear aggregated and damaged protein from cells declines. Tau pathology is a driver of a variety of neurodegenerative disease and in Alzheimer's disease (AD) it appears to be precipitated by the formation of am...

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Publicat a:Front Mol Biosci
Autors principals: Roe, Mark S., Wahab, Ben, Török, Zsolt, Horváth, Ibolya, Vigh, László, Prodromou, Chrisostomos
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6000670/
https://ncbi.nlm.nih.gov/pubmed/29930942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00051
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