Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia

The DosR regulon is believed to be a key factor in latency adaptation of Mycobacterium tuberculosis and is strongly induced by multiple stresses, including hypoxia. Previous studies have revealed reversible acetylation of the conserved core DNA-binding lysine residue 182 (K182) of DosR in M. tubercu...

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Detalhes bibliográficos
Publicado no:Emerg Microbes Infect
Main Authors: Bi, Jing, Gou, Zongchao, Zhou, Fengzhu, Chen, Yiqing, Gan, Jianhua, Liu, Jun, Wang, Honghai, Zhang, Xuelian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999986/
https://ncbi.nlm.nih.gov/pubmed/29899473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41426-018-0112-3
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