SAR Studies on Truxillic Acid Mono Esters as a New Class of Antinociceptive Agents Targeting Fatty Acid Binding Proteins

Fatty acid binding proteins (FABPs) serve as critical modulators of endocannabinoid signaling by facilitating the intracellular transport of anandamide and whose inhibition potentiates anandamide signaling. Our previous work has identified a novel small-molecule FABP inhibitor, α-truxillic acid 1-na...

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書誌詳細
出版年:Eur J Med Chem
主要な著者: Yan, Su, Elmes, Matthew W., Tong, Simon, Hu, Kongzhen, Awwa, Monaf, Teng, Gary Y. H., Jing, Yunrong, Freitag, Matthew, Gan, Qianwen, Clement, Timothy, Wei, Longfei, Sweeney, Joseph M., Joseph, Olivia M., Che, Joyce, Carbonetti, Gregory S., Wang, Liqun, Bogdan, Diane M., Falcone, Jerome, Smietalo, Norbert, Zhou, Yuchen, Ralph, Brian, Hsu, Hao-Chi, Li, Huilin, Rizzo, Robert C., Deutsch, Dale G., Kaczocha, Martin, Ojima, Iwao
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999033/
https://ncbi.nlm.nih.gov/pubmed/29803996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.050
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