Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness

A considerable proportion of tumors exhibit aneuploid karyotypes, likely resulting from the progressive loss of chromosomes after whole-genome duplication. Here, by using isogenic diploid and near-tetraploid (4N) single-cell–derived clones from the same parental cell lines, we aimed at exploring how...

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Veröffentlicht in:FASEB J
Hauptverfasser: Wangsa, Darawalee, Quintanilla, Isabel, Torabi, Keyvan, Vila-Casadesús, Maria, Ercilla, Amaia, Klus, Gregory, Yuce, Zeynep, Galofré, Claudia, Cuatrecasas, Miriam, Lozano, Juan José, Agell, Neus, Cimini, Daniela, Castells, Antoni, Ried, Thomas, Camps, Jordi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998968/
https://ncbi.nlm.nih.gov/pubmed/29452566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700247RR
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