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Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes

BACKGROUND: As one possible solution to the “missing heritability” problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology. However, while a number of methods for pathway-based rare-variant analysis of...

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Veröffentlicht in:BMC Bioinformatics
Hauptverfasser: Lee, Sungyoung, Kim, Yongkang, Choi, Sungkyoung, Hwang, Heungsun, Park, Taesung
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998880/
https://ncbi.nlm.nih.gov/pubmed/29745849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2066-9
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