Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced pluripotent stem cells (iPSCs) from three RP patients with d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cell Reports
Prif Awduron: Deng, Wen-Li, Gao, Mei-Ling, Lei, Xin-Lan, Lv, Ji-Neng, Zhao, Huan, He, Kai-Wen, Xia, Xi-Xi, Li, Ling-Yun, Chen, Yu-Chen, Li, Yan-Ping, Pan, Deng, Xue, Tian, Jin, Zi-Bing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998840/
https://ncbi.nlm.nih.gov/pubmed/29526738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.02.003
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