Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced pluripotent stem cells (iPSCs) from three RP patients with d...

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Detaylı Bibliyografya
Yayımlandı:Stem Cell Reports
Asıl Yazarlar: Deng, Wen-Li, Gao, Mei-Ling, Lei, Xin-Lan, Lv, Ji-Neng, Zhao, Huan, He, Kai-Wen, Xia, Xi-Xi, Li, Ling-Yun, Chen, Yu-Chen, Li, Yan-Ping, Pan, Deng, Xue, Tian, Jin, Zi-Bing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998840/
https://ncbi.nlm.nih.gov/pubmed/29526738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.02.003
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