Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced pluripotent stem cells (iPSCs) from three RP patients with d...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Deng, Wen-Li, Gao, Mei-Ling, Lei, Xin-Lan, Lv, Ji-Neng, Zhao, Huan, He, Kai-Wen, Xia, Xi-Xi, Li, Ling-Yun, Chen, Yu-Chen, Li, Yan-Ping, Pan, Deng, Xue, Tian, Jin, Zi-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998840/
https://ncbi.nlm.nih.gov/pubmed/29526738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.02.003
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