The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the TRPV4 cation channel binds the DEAD-box RNA helicase DDX3X and regulates its...

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Udgivet i:Nat Commun
Main Authors: Doñate-Macián, P., Jungfleisch, J., Pérez-Vilaró, G., Rubio-Moscardo, F., Perálvarez-Marín, A., Diez, J., Valverde, M. A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998047/
https://ncbi.nlm.nih.gov/pubmed/29899501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04776-7
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