The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Ghrh(−/−) Mice Is Associated With an Important Splenic Atrophy and Relative B Lymphopenia

A debate is still open about the precise control exerted by the somatotrope GH-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor 1 axis on the immune system. The objective of this study was to directly address this question through the use of Ghrh(−/−) mice that exhibit a sever...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Bodart, Gwennaelle, Farhat, Khalil, Renard-Charlet, Chantal, Becker, Guillaume, Plenevaux, Alain, Salvatori, Roberto, Geenen, Vincent, Martens, Henri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997896/
https://ncbi.nlm.nih.gov/pubmed/29928261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2018.00296
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