Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway

The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and...

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Foilsithe in:Sci Rep
Main Authors: Marton, Lívia, Hajdú, Fanni, Nagy, Gergely N., Kucsma, Nóra, Szakács, Gergely, Vértessy, Beáta G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997628/
https://ncbi.nlm.nih.gov/pubmed/29895950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27183-w
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