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Unnatural Amino Acid Derivatives through Click Chemistry: Synthesis of Triazolylalanine Analogues
A novel tert-butyl 2-(1-oxoisolndolin-2-yl)acetate derivative is selectively alkylated with propargyl bromide in the presence of lithium hexamethyldisilazide. After removal of the tert-butyl protecting group, the resulting N-isoindolinyl (ethynylalanine) derivative is reacted with a series of azides...
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| Publié dans: | Synlett |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5997291/ https://ncbi.nlm.nih.gov/pubmed/29904233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0036-1588510 |
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