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Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
Large RNAs and ribonucleoprotein complexes have powerful therapeutic potential, but effective cell-targeted delivery tools are limited. Aptamers that internalize into target cells can deliver siRNAs (<15 kDa, 19–21 nt/strand). We demonstrate a modular nanostructure for cellular delivery of large,...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995956/ https://ncbi.nlm.nih.gov/pubmed/29891903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04691-x |
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