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Potent block of potassium channels by MEK inhibitor U0126 in primary cultures and brain slices
U0126 (1,4-diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) butadiene), a widely used mitogen-activated protein kinase kinase (MEK) inhibitor, was found to accelerate voltage-gated K(+) channel (K(V)) inactivation in heterologous cells expressing several types of K(V). The goal of this study was to e...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995919/ https://ncbi.nlm.nih.gov/pubmed/29892075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27235-1 |
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