An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Aberrant activation of RAS signalling pathways contributes to aggressive phenotypes of cancer cells. The RAS-targeted therapies for cancer, therefore, have been recognised to be effective; however, current developments on targeting RAS have not advanced due to structural features of the RAS protein....

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Pubblicato in:Nat Commun
Autori principali: Kawauchi, Keiko, Sugimoto, Wataru, Yasui, Takatoshi, Murata, Kohei, Itoh, Katsuhiko, Takagi, Kazuki, Tsuruoka, Takaaki, Akamatsu, Kensuke, Tateishi-Karimata, Hisae, Sugimoto, Naoki, Miyoshi, Daisuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995912/
https://ncbi.nlm.nih.gov/pubmed/29891945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04771-y
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