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Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies
Checkpoint molecules such as programmed death 1 (PD-1) dampen excessive T cell activation to preserve immune homeostasis. PD-1-specific monoclonal antibodies have revolutionized cancer therapy, as they reverse tumour-induced T cell exhaustion and restore CTL activity. Based on this success, decipher...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995819/ https://ncbi.nlm.nih.gov/pubmed/29892077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27125-6 |
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