Subcellular compartmentalization of proximal Gα(q)-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes

G protein–coupled receptors that signal through Gα(q) (G(q) receptors), such as α(1)-adrenergic receptors (α(1)-ARs) or angiotensin receptors, share a common proximal signaling pathway that activates phospholipase Cβ1 (PLCβ1), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)) to produce i...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dahl, Erika F., Wu, Steven C., Healy, Chastity L., Harsch, Brian A., Shearer, Gregory C., O'Connell, Timothy D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995527/
https://ncbi.nlm.nih.gov/pubmed/29610273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002283
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