TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c(+) adipose tissue macrophage production in obese mice

Obesity-induced chronic inflammation is associated with metabolic disease. Results from mouse models utilizing a high-fat diet (HFD) have indicated that an increase in activated macrophages, including CD11c(+) adipose tissue macrophages (ATMs), contributes to insulin resistance. Obesity primes myelo...

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Vydáno v:J Biol Chem
Hlavní autoři: Griffin, Cameron, Eter, Leila, Lanzetta, Nico, Abrishami, Simin, Varghese, Mita, McKernan, Kaitlin, Muir, Lindsey, Lane, Jamie, Lumeng, Carey N., Singer, Kanakadurga
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995515/
https://ncbi.nlm.nih.gov/pubmed/29636416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001526
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