Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys(197) and by transmembrane protein aptamers that target it for lysosomal degradation

C-C motif chemokine receptor 5 (CCR5) is a cell surface–associated, immune-regulatory G protein–coupled receptor (GCPR) with seven transmembrane helices. We previously reported the isolation and initial characterization of short artificial transmembrane protein aptamers, named “traptamers,” that spe...

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Vydáno v:J Biol Chem
Hlavní autoři: Petti, Lisa M., Marlatt, Sara A., Luo, Yong, Scheideman, Elizabeth H., Shelar, Ashish, DiMaio, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995508/
https://ncbi.nlm.nih.gov/pubmed/29678881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001067
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