The telomerase inhibitor AZT enhances differentiation and prevents overgrowth of human pluripotent stem cell–derived neural progenitors

Human pluripotent stem cell (hPSC)–based cell-replacement therapy has emerged as a promising approach for addressing numerous neurological diseases. However, hPSC transplantation has the potential to cause human cell overgrowth and cancer, which represents a major obstacle to implementing hPSC-based...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hu, Yao, Fang, Kai-Heng, Shen, Lu-Ping, Cao, Shi-Ying, Yuan, Fang, Su, Yuwen, Xu, Min, Pan, Yufeng, Chen, Yaoyu, Liu, Yan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995503/
https://ncbi.nlm.nih.gov/pubmed/29628445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809889
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