Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genom...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Chang, Chan-Jung, Kotini, Andriana G., Olszewska, Malgorzata, Georgomanoli, Maria, Teruya-Feldstein, Julie, Sperber, Henrik, Sanchez, Roberto, DeVita, Robert, Martins, Timothy J., Abdel-Wahab, Omar, Bradley, Robert K., Papapetrou, Eirini P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995368/
https://ncbi.nlm.nih.gov/pubmed/29681544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.03.020
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