Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice

Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and broader specificity membrane-associated lipid phosphate phosphatases (LPPs) that can also dephosphorylate PA. Inactivation of...

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Veröffentlicht in:PLoS One
Hauptverfasser: Federico, Lorenzo, Yang, Liping, Brandon, Jason, Panchatcharam, Manikandan, Ren, Hongmei, Mueller, Paul, Sunkara, Manjula, Escalante-Alcalde, Diana, Morris, Andrew J., Smyth, Susan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995365/
https://ncbi.nlm.nih.gov/pubmed/29889835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198063
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