Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice

Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia‐induced endothelial dysfunction by improving arginine availability for nitric oxide production. Endothelial Arg1‐deficient mice (Arg1‐KO(T) (ie2)) were generated by crossing Arg1 (fl/fl) (controls) with Tie2Cre (tg/−) m...

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Udgivet i:Physiol Rep
Main Authors: Chennupati, Ramesh, Meens, Merlijn J., Janssen, Ben J., van Dijk, Paul, Hakvoort, Theodorus B. M., Lamers, Wouter H., De Mey, Jo G. R., Koehler, S. Eleonore
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995309/
https://ncbi.nlm.nih.gov/pubmed/29890043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13717
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