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Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation

Chimeric mice have been generated by injecting pluripotent stem cells into morula-to-blastocyst stage mouse embryo or by introducing more mature cells into later stage embryos that correspond to the differentiation stage of the donor cells. It has not been rigorously tested, however, whether success...

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Pubblicato in:Stem Cell Reports
Autori principali: Cohen, Malkiel A., Markoulaki, Styliani, Jaenisch, Rudolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995271/
https://ncbi.nlm.nih.gov/pubmed/29606614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.03.004
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