BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

Cancer cells display differences regarding their engagement of glycolytic vs. mitochondrial oxidative phosphorylation (OXPHOS) pathway. Triple negative breast cancer, an aggressive form of breast cancer, is characterized by elevated glycolysis, while estrogen receptor positive breast cancer cells re...

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Vydáno v:Oncotarget
Hlavní autoři: Lucantoni, Federico, Düssmann, Heiko, Llorente-Folch, Irene, Prehn, Jochen H.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995245/
https://ncbi.nlm.nih.gov/pubmed/29899841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25433
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