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BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

Cancer cells display differences regarding their engagement of glycolytic vs. mitochondrial oxidative phosphorylation (OXPHOS) pathway. Triple negative breast cancer, an aggressive form of breast cancer, is characterized by elevated glycolysis, while estrogen receptor positive breast cancer cells re...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lucantoni, Federico, Düssmann, Heiko, Llorente-Folch, Irene, Prehn, Jochen H.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995245/
https://ncbi.nlm.nih.gov/pubmed/29899841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25433
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