Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome

BACKGROUND: The Down syndrome (DS) population is genetically predisposed to amyloid-β protein precursor overproduction and Alzheimer’s disease (AD). OBJECTIVE: The temporal ordering and spatial association between amyloid-β, glucose metabolism, and gray matter (GM) volume in the DS population can pr...

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Udgivet i:J Alzheimers Dis
Main Authors: Lao, Patrick J., Handen, Ben L., Betthauser, Tobey J., Mihaila, Iulia, Hartley, Sigan L., Cohen, Annie D., Tudorascu, Dana L., Bulova, Peter D., Lopresti, Brian J., Tumuluru, Rameshwari V., Murali, Dhanabalan, Mathis, Chester A., Barnhart, Todd E., Stone, Charles K., Price, Julie C., Devenny, Darlynne A., Johnson, Sterling C., Klunk, William E., Christian, Bradley T.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994924/
https://ncbi.nlm.nih.gov/pubmed/29254096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170720
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