Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome

BACKGROUND: The Down syndrome (DS) population is genetically predisposed to amyloid-β protein precursor overproduction and Alzheimer’s disease (AD). OBJECTIVE: The temporal ordering and spatial association between amyloid-β, glucose metabolism, and gray matter (GM) volume in the DS population can pr...

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Bibliographic Details
Published in:J Alzheimers Dis
Main Authors: Lao, Patrick J., Handen, Ben L., Betthauser, Tobey J., Mihaila, Iulia, Hartley, Sigan L., Cohen, Annie D., Tudorascu, Dana L., Bulova, Peter D., Lopresti, Brian J., Tumuluru, Rameshwari V., Murali, Dhanabalan, Mathis, Chester A., Barnhart, Todd E., Stone, Charles K., Price, Julie C., Devenny, Darlynne A., Johnson, Sterling C., Klunk, William E., Christian, Bradley T.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994924/
https://ncbi.nlm.nih.gov/pubmed/29254096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170720
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