Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs

Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within b...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Du, Xiaoping, Cai, Qunfeng, West, Matthew B., Youm, Ibrahima, Huang, Xiangping, Li, Wei, Cheng, Weihua, Nakmali, Don, Ewert, Donald L., Kopke, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993961/
https://ncbi.nlm.nih.gov/pubmed/29680697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.004
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