Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs

Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within b...

詳細記述

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書誌詳細
出版年:Mol Ther
主要な著者: Du, Xiaoping, Cai, Qunfeng, West, Matthew B., Youm, Ibrahima, Huang, Xiangping, Li, Wei, Cheng, Weihua, Nakmali, Don, Ewert, Donald L., Kopke, Richard D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Gene & Cell Therapy 2018
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993961/
https://ncbi.nlm.nih.gov/pubmed/29680697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.004
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