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Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH

Peroxisome-proliferator-activated-receptor-gamma (PPAR-γ) is implicated, in some capacity, in the pathogenesis of pulmonary arterial hypertension (PAH). Rosiglitazone, an oral antidiabetic and PPAR-γ agonist, has the potential to dilate pulmonary arteries and to attenuate arterial remodeling in PAH....

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Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Rashid, Jahidur, Alobaida, Ahmad, Al-Hilal, Taslim A., Hammouda, Samia, McMurtry, Ivan F., Nozik-Grayck, Eva, Stenmark, Kurt R, Ahsan, Fakhrul
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993641/
https://ncbi.nlm.nih.gov/pubmed/29723610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.04.049
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