Haplo-insufficiency of Bcl2-associated Athanogene 3 in Mice Results in Progressive Left Ventricular Dysfunction, β-Adrenergic Insensitivity and Increased Apoptosis

Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart, skeletal muscle and many cancers. Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. To study the cellular...

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Vydáno v:J Cell Physiol
Hlavní autoři: Myers, Valerie D., Tomar, Dhanendra, Madesh, Muniswamy, Wang, JuFang, Song, Jianliang, Zhang, Xue-Qian, Gupta, Manish K., Tahrir, Farzaneh G., Gordon, Jennifer, McClung, Joseph M., Kontos, Christopher D., Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993591/
https://ncbi.nlm.nih.gov/pubmed/29323723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26482
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