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An Improved Fast Photochemical Oxidation of Proteins (FPOP) Platform for Protein Therapeutics

Unlike small-molecule drugs, the size and dynamics of protein therapeutics challenge existing methods for assessing their high order structure (HOS). To extend Fast Photochemical Oxidation of Proteins (FPOP) to protein therapeutics, we modified its platform by introducing a mixing step prior to lase...

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Detalhes bibliográficos
Publicado no:J Am Soc Mass Spectrom
Main Authors: Zhang, Ying, Rempel, Don L., Zhang, Hao, Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993200/
https://ncbi.nlm.nih.gov/pubmed/25519854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-014-1055-0
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