Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator

Loss of integrity of the blood-brain barrier (BBB) in ischemic stroke victims initiates a devastating cascade of events causing brain damage. Maintaining the BBB is important to preserve brain function in ischemic stroke. Unfortunately, recombinant tissue plasminogen activator (tPA), the only effect...

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Udgivet i:PLoS One
Main Authors: Shimada, Yoshiaki, Shimura, Hideki, Tanaka, Ryota, Yamashiro, Kazuo, Koike, Masato, Uchiyama, Yasuo, Urabe, Takao, Hattori, Nobutaka
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993064/
https://ncbi.nlm.nih.gov/pubmed/29795667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198039
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