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A “Cross-Stitched” Peptide with Improved Helicity and Proteolytic Stability
A new computational approach to obtain quantitative energy profiles for helix folding was used in the design of orthogonal hydrocarbon and lactam bicyclic peptides. The proteolytically stable,“cross-stitched” peptide SRC2-BCP1 shows nanomolar affinity for estrogen receptor α and x-ray crystallograph...
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| Publicado en: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5993042/ https://ncbi.nlm.nih.gov/pubmed/29725689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob00790j |
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