The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

BACKGROUND: Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. METHODS: We prospectively recruited patients...

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Dettagli Bibliografici
Pubblicato in:Eur Stroke J
Autori principali: Makin, Stephen DJ, Doubal, Fergus N, Quinn, Terence J, Bath, Philip MW, Dennis, Martin S, Wardlaw, Joanna M
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2017
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Original Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992736/
https://ncbi.nlm.nih.gov/pubmed/29900411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2396987317728854
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