Agomelatine protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Agomelatine is a melatonin (MT1/MT2) receptor agonist and serotonin (5-HT2C) receptor antagonist. To study the effects of agomelatine on myocardial ischemia reperfusion injury (MIRI), an isolated rat heart model was utilized. To induce MIRI, rat hearts were isolated and subjected to 30 min of ischem...

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Vydáno v:Am J Transl Res
Hlavní autoři: Jia, Pengyu, Liu, Chunting, Wu, Nan, Jia, Dalin, Sun, Yingxian
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992559/
https://ncbi.nlm.nih.gov/pubmed/29887947
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