Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used clinically as target therapies for lung cancer patients, but the occurrence of acquired drug resistance limits their efficacy. Nicotinamide N-methyltransferase (NNMT), a cancer-associated metabolic enzyme, is commonly o...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Bach, Duc-Hiep, Kim, Donghwa, Bae, Song Yi, Kim, Won Kyung, Hong, Ji-Young, Lee, Hye-Jung, Rajasekaran, Nirmal, Kwon, Soonbum, Fan, Yanhua, Luu, Thi-Thu-Trang, Shin, Young Kee, Lee, Jeeyeon, Lee, Sang Kook
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992482/
https://ncbi.nlm.nih.gov/pubmed/29858080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.03.011
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