miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Prognosis is poor, and therapeutic options are limited. MicroRNAs (miRNAs) have emerged as potential therapeutic molecules against cancer. Here, we investigated the therapeutic efficacy of miR-199a-3p, an m...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Callegari, Elisa, D’Abundo, Lucilla, Guerriero, Paola, Simioni, Carolina, Elamin, Bahaeldin K., Russo, Marta, Cani, Alice, Bassi, Cristian, Zagatti, Barbara, Giacomelli, Luciano, Blandamura, Stella, Moshiri, Farzaneh, Ultimo, Simona, Frassoldati, Antonio, Altavilla, Giuseppe, Gramantieri, Laura, Neri, Luca Maria, Sabbioni, Silvia, Negrini, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992479/
https://ncbi.nlm.nih.gov/pubmed/29858083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.04.002
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