Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis

γδ T cell-based immunotherapy for osteosarcoma (OS) has shown limited success thus far. DNA-demethylating agents not only induce tumor cell death but also have an immunomodulatory function. In this study, we have assessed the potential benefit of combining decitabine (DAC, a DNA demethylation drug)...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Zhan, Wang, Zenan, Li, Shu, Li, Binghao, Sun, Lingling, Li, Hengyuan, Lin, Peng, Wang, Shengdong, Teng, Wangsiyuan, Zhou, Xingzhi, Ye, Zhaoming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992281/
https://ncbi.nlm.nih.gov/pubmed/29910819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01239
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