HuR regulates telomerase activity through TERC methylation

Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates with TERC and promotes the assembly of the TERC/TERT complex by facilita...

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Published in:Nat Commun
Main Authors: Tang, Hao, Wang, Hu, Cheng, Xiaolei, Fan, Xiuqin, Yang, Fan, Zhang, Mengmeng, Chen, Yanlian, Tian, Yuyang, Liu, Cihang, Shao, Dongxing, Jiang, Bin, Dou, Yali, Cong, Yusheng, Xing, Junyue, Zhang, Xiaotian, Yi, Xia, Songyang, Zhou, Ma, Wenbin, Zhao, Yong, Wang, Xian, Ma, Jinbiao, Gorospe, Myriam, Ju, Zhenyu, Wang, Wengong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992219/
https://ncbi.nlm.nih.gov/pubmed/29880812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04617-7
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