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Arginase and α-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia

The L-arginine/NO pathway is an important regulator of pulmonary hypertension, the leading cause of mortality in patients with the chronic lung disease of prematurity, bronchopulmonary dysplasia. L-arginine can be metabolized by NO synthase (NOS) to form L-citrulline and NO, a potent vasodilator. Al...

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Detalhes bibliográficos
Publicado no:Clin Exp Pharmacol Physiol
Main Authors: Trittmann, Jennifer K, Velten, Markus, Heyob, Kathryn M, Almazroue, Hanadi, Jin, Yi, Nelin, Leif D, Rogers, Lynette K
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991998/
https://ncbi.nlm.nih.gov/pubmed/29266319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1440-1681.12909
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