Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained by Polycomb Repressive Complexes (PRCs). Her...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ma, Zaijun, Wang, Hui, Cai, Yuping, Wang, Han, Niu, Kongyan, Wu, Xiaofen, Ma, Huanhuan, Yang, Yun, Tong, Wenhua, Liu, Feng, Liu, Zhandong, Zhang, Yaoyang, Liu, Rui, Zhu, Zheng-Jiang, Liu, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991832/
https://ncbi.nlm.nih.gov/pubmed/29809154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35368
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