Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis

The present study demonstrates HIV-1 Tat-mediated epigenetic downregulation of microglial miR-124 and its association with microglial activation. Exposure of mouse primary microglia isolated from newborn pups of either sex to HIV-1 Tat resulted in decreased expression of primary miR-124-1, primary m...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Periyasamy, Palsamy, Thangaraj, Annadurai, Guo, Ming-Lei, Hu, Guoku, Callen, Shannon, Buch, Shilpa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990983/
https://ncbi.nlm.nih.gov/pubmed/29760177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3474-17.2018
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