Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

We have recently shown that male Rhes knockout (KO) mice develop a mild form of spontaneous Parkinson’s disease (PD)-like phenotype, characterized by motor impairment and a decrease in nigrostriatal dopamine (DA) neurons. Experimental evidence has implicated neuroinflammation in PD progression, and...

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Bibliografiske detaljer
Udgivet i:Front Aging Neurosci
Main Authors: Costa, Giulia, Pinna, Annalisa, Porceddu, Pier Francesca, Casu, Maria Antonietta, Di Maio, Anna, Napolitano, Francesco, Usiello, Alessandro, Morelli, Micaela
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990628/
https://ncbi.nlm.nih.gov/pubmed/29904346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00163
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