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PARP Inhibition in BRCA-Mutant Breast Cancer
Individuals with BRCA1 or BRCA2 germline mutations have a significantly increased lifetime risk for breast and ovarian cancers. BRCA-mutant cancer cells have abnormal Homologous Recombination (HR) repair of DNA. In these tumors, the Base Excision Repair (BER) pathway is important for cell survival....
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| Pubblicato in: | Cancer |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5990439/ https://ncbi.nlm.nih.gov/pubmed/29660759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.31307 |
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