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Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank

Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown. Here we provide evidence that part of the missing heritability can be explained by an overestimation of heritability...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Muñoz, María, Pong-Wong, Ricardo, Canela-Xandri, Oriol, Rawlik, Konrad, Haley, Chris S., Tenesa, Albert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989924/
https://ncbi.nlm.nih.gov/pubmed/27428752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3618
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