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RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling
The production of type I interferon (IFN) is essential for cellular barrier functions and innate and adaptive antiviral immunity. In response to virus infections, RNA receptors RIG‐I and MDA5 stimulate a mitochondria‐localized signaling apparatus that uses TRAF family ubiquitin ligase proteins to ac...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5989757/ https://ncbi.nlm.nih.gov/pubmed/29661858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745176 |
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