Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation

Human hematopoiesis involves cellular differentiation of multipotent cells into progressively more lineage-restricted states. While the chromatin accessibility landscape of this process has been explored in defined populations, single-cell regulatory variation has been hidden by ensemble averaging....

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Gepubliceerd in:Cell
Hoofdauteurs: Buenrostro, Jason D, Corces, M Ryan, Lareau, Caleb A, Wu, Beijing, Schep, Alicia N, Aryee, Martin, Majeti, Ravindra, Chang, Howard Y., Greenleaf, William J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989727/
https://ncbi.nlm.nih.gov/pubmed/29706549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.074
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