Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

BACKGROUND: Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of...

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Détails bibliographiques
Publié dans:BMC Biol
Auteurs principaux: Mead, Benjamin E., Ordovas-Montanes, Jose, Braun, Alexandra P., Levy, Lauren E., Bhargava, Prerna, Szucs, Matthew J., Ammendolia, Dustin A., MacMullan, Melanie A., Yin, Xiaolei, Hughes, Travis K., Wadsworth, Marc H., Ahmad, Rushdy, Rakoff-Nahoum, Seth, Carr, Steven A., Langer, Robert, Collins, James J., Shalek, Alex K., Karp, Jeffrey M.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989470/
https://ncbi.nlm.nih.gov/pubmed/29871632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0527-2
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