Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

BACKGROUND: Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of...

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Udgivet i:BMC Biol
Main Authors: Mead, Benjamin E., Ordovas-Montanes, Jose, Braun, Alexandra P., Levy, Lauren E., Bhargava, Prerna, Szucs, Matthew J., Ammendolia, Dustin A., MacMullan, Melanie A., Yin, Xiaolei, Hughes, Travis K., Wadsworth, Marc H., Ahmad, Rushdy, Rakoff-Nahoum, Seth, Carr, Steven A., Langer, Robert, Collins, James J., Shalek, Alex K., Karp, Jeffrey M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989470/
https://ncbi.nlm.nih.gov/pubmed/29871632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0527-2
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